|
KMID : 0923620150150050232
|
|
Immune Network
2015 Volume.15 No. 5 p.232 ~ p.240
|
|
|
A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages
|
|
:Won Kyung-Jong
:Park Sung-Won/:Lee Seung-hoon/:Kong Il-Keun/:Chae Jung-Il/:Kim Bo-Kyung/:Lee Eun-Jong/:Kim Dong-Ku
|
|
|
Abstract
|
|
|
|
The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages.
|
|
|
KEYWORD
|
|
|
TLT-6, ITIM motif, Anti-proliferation, Macrophages, TREM family
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|